Manuel Cantu Gutierrez

Manuel Cantu Gutierrez

Staff Scientist

Children's Hospital of Philadelphia

Biography

Welcome πŸ‘¨πŸ»πŸ’»! I am a Staff Scientist in the Lingappan Lab at Children’s Hopsital of Philadelphia. Originally from Mexico I moved to Texas to pursue a Biology degree at The University of Texas-Pan American.

In college, I studied neurodegeneration using pond snails (I know, not the fastest animal model) while completing my undergraduate education at UTPA (now UTRGV) in Dr Dan Plas’ laboratory. Also as an undergraduate student and thanks to HHMI EXROP, I got the opportunity to perform research in Dr Hugo Bellen’s lab at BCM helping in the development of a genetic tool that allows for the tagging of genes and a reversible, spatial and temporal knockdown of proteins in fruit flies.

Those experiences showed me the power of genetics and model organisms to the advance of our understanding of basic developmental biology and human disease. I started my PhD in Developmental Biology in the summer of 2015 and joined the Wythe Lab in 2016. My research in the Wythe Lab focused on the study the molecular mechanisms that regulate angiogenesis during development using zebrafish and mice as model organisms.

Now in the Lingappan lab, I am interested in understanding the sex-specific developmental reponse to lung injury. More specifically, my goal is to better understand what happens in premature babies that develop bronchopulmonary displasya (BPD) in a mouse model of hyperxic injury with the hope that it will eventually lead to better and targetted treatments.

Interests
  • Endothelial Cell Development
  • Lung Injury and Regeneration
  • Bioinformatics and imaging
Education
  • PhD in Developmental Biology, 2021

    Baylor College of Medicine

  • B.S. in Biology, 2015

    University of Texas-Pan American

Skills

Technical
Fluorescence Microscopy

Trained in use of confocal and lightsheet microscopy

Molecular Biology Techniques

Use and design of experiments related to the study of DNA/RNA/Proteins

R for Bioinformatics

Basic use of R to process next generation sequencing data including RNA-Seq, ATAC-Seq and Single Cell Sequencing

Lab Survival Surgery

Trained in use of survival surgery techniques to study development and regeneration.

Hobbies
Hiking and Camping
Books, books, books
Long Distance Running

Experience

 
 
 
 
 
Staff Scientist
February 2021 – Present Pennsylvania

Responsibilities include:

  • Project management
  • Training
  • Documentation and Reporting
 
 
 
 
 
Graduate Researcher
May 2015 – December 2021 Texas
Endothelial cell maturation during development and its role during glioblastoma formation and treatment resistance.

Gallery

Recent Publications

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(2023). Modulation of recovery from neonatal hyperoxic lung injury by sex as a biological variable. Redox Biology.

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(2023). Molecular insights using spatial transcriptomics of the distal lung in congenital diaphragmatic hernia. American Journal of Physiology-Lung Cellular and Molecular Physiology.

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(2023). Loss of growth differentiation factor 15 exacerbates lung injury in neonatal mice. American Journal of Physiology-Lung Cellular and Molecular Physiology.

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(2023). Endothelial to mesenchymal transition in neonatal hyperoxic lung injury: role of sex as a biological variable. Physiological Genomics.

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(2023). Remarkable sex-specific differences at single-cell resolution in neonatal hyperoxic lung injury. American Journal of Physiology-Lung Cellular and Molecular Physiology.

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